Rikke Sofie Kuhre on Muck Rack

Rikke Sofie Kuhre

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Articles

Aberrant MET activation impairs perinuclear actin cap organization with YAP1 cytosolic relocation - Communications Biology

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By Spartaco Santi, Enea Ferlizza, Carola Cavallo, Donatella Romaniello, Michela Sgarzi, Rikke Sofie Kuhre
| Nature Verified
Abstract Little is known about the signaling network responsible for the organization of the perinuclear actin cap, a recently identified structure holding unique roles in the regulation of nuclear shape and cell directionality. In cancer cells expressing a constitutively active MET, we show a rearrangement of the actin cap filaments, which crash into perinuclear patches associated with spherical nuclei, meandering cell motility and inactivation of the mechano-transducer YAP1.
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