Rina Baba on Muck Rack

Rina Baba

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Articles

LSD1 enzyme inhibitor TAK-418 unlocks aberrant epigenetic machinery and improves autism symptoms in neurodevelopmental disorder models

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By Yuuichi Arakawa, Rina Baba, Satoru Matsuda, Ryuji Yamada
| Science Magazine Verified
Abstract Persistent epigenetic dysregulation may underlie the pathophysiology of neurodevelopmental disorders, such as autism spectrum disorder (ASD). Here, we show that the inhibition of lysine-specific demethylase 1 (LSD1) enzyme activity normalizes aberrant epigenetic control of gene expression in neurodevelopmental disorders.
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