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Rion Komuro

As seen in: Nature
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Articles

Structural basis of condensate formation of VAPB protein

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By Kyoko Furuita, Naohiro Kobayashi, Takashi S. Kodama, Yohei Miyanoiri, Toshimichi Fujiwara, Chojiro Kojima, Mayu Enomoto-Kusano, Wataru Togawa, Rion Komuro, Kengo Nakayama
| Nature Verified
Abstract Vesicle-associated membrane protein-associated protein B (VAPB) is an endoplasmic reticulum protein implicated in amyotrophic lateral sclerosis (ALS) through its P56S mutation. Although pathological function loss and condensate formation of the VAPB P56S mutant are crucial for disease progression, the underlying molecular mechanism remains unclear.
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