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Riri Kwon on Muck Rack

Riri Kwon

As seen in: BioRxiv
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Articles

B lymphocytes acquire myeloid and autoimmune phenotypes via the downregulation of lymphocyte-specific protein-1

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By Bong-Ki Hong, Sungyong You, Naeun Lee, Riri Kwon
| BioRxiv
Abstract Actin-binding proteins (ABPs) have been established as important mediators of immune homeostasis, but their effects on lymphocytes are poorly understood. Here, we demonstrated that LSP1, an ABP, is a master regulator for innate immune responses in B lymphocytes. Lsp1 deficiency in B cells upregulated the expression of myeloid genes, including CD11b, CD11c, and myeloperoxidase, and bestowed myeloid morphology.
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