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RM Carletti on Muck Rack

RM Carletti

As seen in: Nature
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Articles

Mutant Huntingtin disrupts neurogenic and astroglial programs via the EZH2–Let-7g–LIN28 axis with rescue by epigenetic modulators

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By D. D’Andrea, M. Ciavarella, A. Rinaldi, A. De Luca, S. Valente, M. Gelati, D. Ferrari, M. Catalano, M. Biagioli, M. G. Basso, B. D. Reynolds, JD Rosati, A. Casamassa, G. Ruotolo, AMG Giovenale, G. Rotundo, A. D’Anzi, EM Turco, G. Bergonzoni, A. Visioli, I. Lombardi, RM Carletti, U. Cappucci, A. Migazzi, C. Bertollini, V. Giambra, D. Rotili, E. Binda, O. Palumbo, F. Squitieri, L. Piacentini, S. Di Angelantonio, A. Mai, M. Pennuto, AL Vescovi
| Nature Verified
Abstract The molecular mechanisms by which mutant huntingtin (mHTT) drives pathogenesis in Huntington’s disease (HD) remain incompletely defined. Here we show that neurogenesis is disrupted at multiple stages of lineage progression in both rodent and human neural stem cell (NSC) models of HD.
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