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Integrins are essential receptors that control interactions between cells and their surroundings by transmitting mechanical and biochemical signals [1], [2], [3]. Integrins are important for several cell signalling pathways that control fundamental processes such as survival, proliferation, differentiation, and migration [4]. As heterodimeric proteins composed by α and β subunits, 24 types of integrins are present on the surface of mammalian cells.
Living cells continually interact with their extracellular matrix (ECM) through cell surface receptors and ligands, facilitating diverse cellular behaviors, such as proliferation, migration, differentiation, and apoptosis [1], [2], [3]. Integrins, for instance, bind to cell-adhesive moieties, such as the Arg-Gly-Asp (RGD) tripeptide sequences present in fibronectin, vitronectin, and collagen [4], [5], [6].
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