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Roaia Shibli

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Articles

Life‐threatening bronchospasm induced by an angiotensin‐converting enzyme inhibitor in a chronically ventilated patient: Diagnostic pitfalls and literature review

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By Esther-Lee Marcus, Amir Hush, Hisham Atrash, Roaia Shibli
| Wiley Online Library Verified
INTRODUCTION Introducing angiotensin-converting-enzyme inhibitors (ACEi) and angiotensin II-AT1-receptor blockers (ARBs) attenuates hypertension and provides substantial cardio-renal protection with reduced mortality.1-4 This reflects the suppression of the ‘pressor’ renin/angII/AT1R/aldosterone axis, which, in addition to vasoconstriction, stimulates inflammation, fibrosis, hypercoagulation, and apoptosis, generating hypertension and progressive vascular, myocardial, and renal injury.
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