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Rob Barringer

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Articles

Interrogation of an enzyme library reveals the catalytic plasticity of naturally evolved [4+2] cyclases

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By Katja Zorn, Catherine R Back, Rob Barringer, Veronika Chadimová
| Wiley Online Library Verified
Abstract Stereoselective carbon-carbon bond forming reactions are quintessential transformations in organic synthesis. One example is the Diels-Alder reaction, a [4+2] cycloaddition between a conjugated diene and a dienophile to form cyclohexenes. The development of biocatalysts for this reaction is paramount for unlocking sustainable routes to a plethora of important molecules.
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