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Roba Abukwaik

As seen in: BioRxiv
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Articles

P53 Orchestrates Cancer Metabolism: Unveiling Strategies to Reverse the Warburg Effect

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By Elias Vera-Siguenza, Daniel A. Tennant, Fabian Spill, Roba Abukwaik
| BioRxiv
Abstract Cancer cells exhibit significant alterations in their metabolism, characterised by a reduction in oxidative phosphorylation (OXPHOS) and an increased reliance on glycolysis, even in the presence of oxygen. This metabolic shift, known as the Warburg effect, is pivotal in fuelling cancer's uncontrolled growth, invasion, and therapeutic resistance. While dysregulation of many genes contributes to this metabolic shift, the tumour suppressor gene p53 emerges as a master player.
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