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Robert Bartha

As seen in: Color Research & Application, Nature, International Journal of Biomedical Imaging
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Articles

Peripheral cytochrome P450-soluble epoxide hydrolase oxylipins and Alzheimer’s disease progression

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By William Lin, Natasha Z. Anita, Sofia E. Perfetto, Qing Shen, Maria Moran-Garrido, Joel Ramirez, Joel Ramírez, Maged Goubran, Jennifer Rabin, Bradley J. MacIntosh, Maria Carmela Tartaglia, Angela Roberts, Malcolm Binns, Robert Bartha, Sean P. Symons, Allison A. Dilliott, Robert A. Hegele, Paula McLaughlin, Henrik Zetterberg, Richard Swartz, Mario Masellis, Sandra Black, Ameer Y. Taha, Walter Swardfager, Alexandra Magliocco, Myuri Ruthirakuran, Celine H. L. Huang
| Nature Verified
Abstract Oxylipin species are generated from omega-3 and omega-6 fatty acids during inflammation, including fatty acid epoxides by cytochrome P450s (CYP450) and their diol metabolites by soluble epoxide hydrolase (sEH). The CYP450-sEH pathway has been implicated in Alzheimer’s disease (AD) but it remains unclear how plasma oxylipins relate to AD biomarkers and neurodegeneration.
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Optimized in vivo brain glutamate measurement using long‐echo‐time semi‐LASER at 7 T

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By Dickson Wong Verified, Amy L. Schranz, Robert Bartha
| Arthritis & Rheumatology Verified
A short echo time (T ) is commonly used for brain glutamate measurement by 1H MRS to minimize drawbacks of long T such as signal modulation due to J evolution and T relaxation. However, J coupling causes the spectral patterns of glutamate to change with T , and the shortest achievable T may not produce the optimal glutamate measurement. The purpose of this study was to determine the optimal T for glutamate measurement at 7 T using semi‐LASER (localization by adiabatic selective refocusing).
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