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Articles by Robert Britton
BTK dynamics and function are differentially influenced by distinct covalent inhibitor warhead chemistries.
Abstract Covalent inhibitors are rapidly becoming the standard of care for treatment of a range of disease states. Covalent inhibitors bind irreversibly to their target using a reactive electrophile (or warhead). Acrylamide and 2-butynamide are the most commonly used cysteine targeting electrophiles. These warheads are chosen for their efficient and selective modification of the protein and are presumed to be otherwise functionally inert.
Here’s how scientists aim to speed up drug development for treating new viruses Original
When the COVID-19 pandemic hit, one of the first medicines doctors turned to was remdesivir, part of a family of medicines called nucleoside analogues that are also used to treat HIV, hepatitis and some cancers. These drugs are especially important because there are a surprisingly limited arsenal of drugs that reliably fight viral infections. That’s one of the main reasons why new viral outbreaks cause so much alarm.
Regulating Nonnative Aquatic Species in China Under a Revised Fisheries Law
Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement No data were generated or analysed in this article. References , , , et al. 2023. “Preventing and Controlling Nonnative Species Invasions to Bend the Curve of Global Freshwater Biodiversity Loss.” Environmental Reviews 31, no. 2: 310–326. https://doi.org/10.1139/er-2022-0103. , , , , and . 2008. “China's Booming Economy Is Sparking and Accelerating Biological Invasions.” Bioscience 58, no. 4: 317–324.
Synthetic microbial co-cultures for modular bioelectronic sensing in diverse environments
Abstract Whole-cell bioelectronic sensors are particularly well-suited for environmental and health monitoring as they can be integrated into compact electronic devices for field deployment over extended periods. However, current engineering strategies lack modularity, are limited to a few microbial chassis and depend on specialized instruments for signal detection.
True North and the future we build together for Bucyrus students
Robert Britton Special to Bucyrus Telegraph-Forum Dec. 12, 2025, 5:03 a.m. ET Every student deserves to graduate confident in their future, knowing who they are, what they are good at and how to take their next step in life. In Bucyrus City Schools, this belief has become our driving mission. It’s why we launched True North, our district’s vision for career-connected learning, and it’s why we are calling on our entire community to stand with us as we take this work even further.
Spatial and seasonal patterns in fish assemblages of the Bakırçay river are associated with physicochemical and habitat parameters - Scientific Reports
Abstract The significance of long-term biodiversity monitoring studies for the protection of natural biodiversity and human well-being is well recognised by the Turkish scientific community. Despite understanding the ecological importance of freshwater ecosystems, spatially or temporally congruent studies using high resolution biodiversity monitoring data from Turkish freshwater resources remain scarce.
Restructuring Department Bulletin - August 2025
23andMe Closes Sale to TTAM Research Institute Following Eighth Circuit’s Denial of Motion to Stay On July 14, 2025, 23andMe Holding Co., a leading human genetics and biotechnology company, successfully closed the sale of substantially all of its assets to TTAM Research Institute for $305 million. TTAM is a not-for-profit medical research organization founded by Anne Wojcicki, 23andMe’s co-founder and former CEO.
Independent Directors Properly Exculpated as Debtors’ Disinterested Fiduciaries Under Chapter 11 Plan, Southern District of Texas Bankruptcy Court Rules
On March 3, 2025, Judge Marvin Isgur of the United States Bankruptcy Court for the Southern District of Texas (the “Bankruptcy Court”) held in In re Instant Brands Acquisition Holdings Inc., et al., Case No. 23-90716 (“Instant Brands”) that the Debtors’ chapter 11 plan (the “Plan”) properly exculpated the Debtors’ independent directors for conduct performed within the scope of their duties during the administration of the chapter 11 cases, absent gross negligence or willful misconduct.[1] The...
A sequential esterification-ring closing metathesis-Nozaki-Hiyama-Kishi strategy for constructing a natural product-like library of tetrahydrofuran-containing macrolides - Chemical Science (RSC Publishing)
A sequential esterification-ring closing metathesis-Nozaki–Hiyama–Kishi strategy for constructing a natural product-like library of tetrahydrofuran-containing macrolides† Polyketide-like macrolides (pMLs) represent a privileged class of compounds with a high incidence of bioactivity, however their structural complexity challenges their synthesis and more general study.
Restructuring Department Bulletin - March 2025
In the March 2025 edition of the Restructuring Department Bulletin, we highlight recent decisions and developments impacting the restructuring arena and share the latest news on the Paul, Weiss Restructuring Department.
Three’s a Crowd? The Thames Water Restructuring Plan(s)
In one of the most high-profile and hotly-watched cases in the London restructuring market, on 18 February 2025, the English High Court approved the restructuring plan proposed by Thames Water. The Court gave permission to appeal the Court’s order to a group of challenging junior creditors, a subordinated creditor and Liberal Democrat MP Charlie Maynard, with the Court of Appeal due to sit from 11 to 13 March 2025.
"Microbial Stimulation of Oxytocin Release From the Intestinal Epitheli" by Heather A Danhof, Jihwan Lee et al.
Keywords Humans, Animals, Mice, Secretin, Oxytocin, Gastrointestinal Microbiome, Gastrointestinal Hormones, Intestinal Mucosa, Limosilactobacillus reuteri, Limosilactobacillus reuteri, lactobacillus reuteri, oxytocin, secretin, enteroendocrine cells, neuropeptide hormone, gut-brain axis, enteroids, organoids, human, mouse, pig Abstract Intestinal microbes impact the health of the intestine and organs distal to the gut.
Early life microbial succession in the gut follows common patterns in humans across the globe - Nature Communications
Abstract Characterizing the dynamics of microbial community succession in the infant gut microbiome is crucial for understanding child health and development, but no normative model currently exists. Here, we estimate child age using gut microbial taxonomic relative abundances from metagenomes, with high temporal resolution (±3 months) for the first 1.5 years of life.
A flexible and scalable synthesis of 4′-thionucleosides
A flexible and scalable synthesis of 4′-thionucleosides† 4′-Thionucleosides (thNAs) are synthetic nucleoside analogues that have attracted attention as leads for drug discovery in oncology and virology. Here we report a de novo thNA synthesis that relies on a scalable α-fluorination and aldol reaction of α-heteroaryl acetaldehydes followed by a streamlined process involving carbonyl reduction, mesylate formation and a double displacement reaction using NaSH.
Third Circuit Rules on Allowance of Make-Whole Fees and Post-Petition Interest in Solvent-Debtor Cases in In re The Hertz Corp.
On September 10, 2024, the U.S. Court of Appeals for the Third Circuit issued its opinion in Wells Fargo Bank, N.A. v. The Hertz Corp. (In re The Hertz Corp.), Case No. 23-1169, 2024 WL 4132132 (3d Cir. Sept. 10, 2024), regarding payment of make-whole fees and post-petition interest in solvent-debtor cases.
Restructuring Department Bulletin - September 2024
Supreme Court Reaffirms Fraudulent Transfer Actions Are “Suits at Common Law” That Must Be Heard by a Jury In Sec. & Exch. Comm’n v. Jarkesy, 144 S. Ct. 2117 (2024), the Supreme Court held that the Securities and Exchange Commission’s (“SEC”) adjudication of securities fraud claims before an administrative law judge rather than an Article III court with a jury violates the Seventh Amendment.
Limosilactobacillus reuteri promotes the expression and secretion of enteroendocrine- and enterocyte derived hormones
Abstract Observations that intestinal microbes can beneficially impact host physiology have prompted investigations into the therapeutic usage of such microbes in a range of diseases. For example, the human intestinal microbe Limosilactobacillus reuteri strains ATCC PTA 6475 and DSM 17938 are being considered for use for intestinal ailments including colic, infection, and inflammation as well as non-intestinal ailments including osteoporosis, wound healing, and autism spectrum disorder.
Restructuring Department Bulletin - June 2024
Alice Eaton and Sean Mitchell Discuss Paul, Weiss’s Restructuring Practice in Vault Q&A Alice and Sean describe the breadth of Paul, Weiss’s Restructuring practice and what sets the practice apart in a Q&A in the 2024 edition of “Practice Perspectives: Vault’s Guide to Legal Practice Areas.” Elizabeth McColm and Sean Mitchell Publish “USA” Chapter in ICLG – Restructuring & Insolvency 2024 In the latest ICLG – Restructuring & Insolvency Laws & Regulations, Elizabeth and Sean discuss common...
A consumer attributions‐based approach for investigating the effect of corporate greenwashing on wishcycling
1 INTRODUCTION AND MOTIVATION The scale of waste production has grown to significant levels globally, posing substantial challenges for both environmental degradation and public health (Basu et al., 2024; Friedrich, 2021). In the UK alone, household waste averages 66 plastic items per week, resulting in approximately 2.5 million metric tons of plastic packaging waste being generated. (Alves, 2023).
Restructuring Department Bulletin - May 2024
Alice Eaton Featured at Wharton’s PE and Venture Capital Conference Restructuring partner Alice Eaton spoke on the panel “Adjusting to a New Era: Redefining Value Creation in Uncertain Times,” as part of the Wharton School of the University of Pennsylvania’s 2024 Private Equity and Venture Capital Conference on March 29. The panel covered the use of innovative financing instruments and structures for investments in distressed assets.
IJMS | Free Full-Text | Resveratrol for the Management of Human Health: How Far Have We Come? A Systematic Review of Resveratrol Clinical Trials to Highlight Gaps and Opportunities
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Enantioselective Total Synthesis of the Marine Macrolides Salarins A and C
Download Hi-Res ImageDownload to MS-PowerPointCite This:J. Am. Chem. Soc. 2024, XXXX, XXX Terms & Conditions Most electronic Supporting Information files are available without a subscription to ACS Web Editions. Such files may be downloaded by article for research use (if there is a public use license linked to the relevant article, that license may permit other uses).
Restructuring Department Bulletin - December 2023
Election of Joe Graham to Partner Joe Graham was elected partner in the New York office. This year, Joe played a leading role in the chapter 11 cases of Avaya, Benefytt and Diamond Sports. He regularly advises on out-of-court restructurings, bankruptcy litigation and distressed investments. Joe earned his J.D., magna cum laude, and his B.A. from the University of Notre Dame.
Impact of the clinically approved BTK inhibitors on the conformation of full-length BTK and analysis of the development of BTK resistance mutations in chronic lymphocytic leukemia.
Abstract Inhibition of Bruton tyrosine kinase (BTK) has proven to be highly effective in the treatment of B-cell malignancies such as chronic lymphocytic leukemia (CLL), autoimmune disorders and multiple sclerosis. Since the approval of the first BTK inhibitor (BTKi), Ibrutinib, several other inhibitors including Acalabrutinib, Zanubrutinib, Tirabrutinib and Pirtobrutinib have been clinically approved.
Development and application of decatungstate catalyzed C-H 18F- and 19F-fluorination, fluoroalkylation and beyond
Development and application of decatungstate catalyzed C–H 18F- and 19F-fluorination, fluoroalkylation and beyond Over the past few decades, photocatalytic C–H functionalization reactions have received increasing attention due to the often mild reaction conditions and complementary selectivities to conventional functionalization processes.
Restructuring Department Bulletin - November 2023
In the November 2023 edition of the Restructuring Department Bulletin, we highlight recent decisions and developments impacting the restructuring arena and share the latest news on the Paul, Weiss Restructuring Department. » read the bulletin In the November 2023 edition of the Restructuring Department Bulletin, we highlight recent decisions and developments impacting the restructuring arena and share the latest news on the Paul, Weiss Restructuring Department.
Restructuring Department Bulletin - October 2023
In the October 2023 edition of the Restructuring Department Bulletin, we highlight recent decisions and developments impacting the restructuring arena and share the latest news on the Paul, Weiss Restructuring Department. » read the bulletin In the October 2023 edition of the Restructuring Department Bulletin, we highlight recent decisions and developments impacting the restructuring arena and share the latest news on the Paul, Weiss Restructuring Department.
~Sole Searching~ ELEVATE
Faith-Fueled Flight By Robert Britton Isaiah 40:31 (NIV) 31) but those who hope in the Lord will renew their strength. They will soar on wings like eagles; they will run and not grow weary, they will walk and not be faint. Flight Equipment
Microbial stimulation of oxytocin release from the intestinal epithelium via secretin signaling
Thank you for your interest in spreading the word about bioRxiv. NOTE: Your email address is requested solely to identify you as the sender of this article. Your Email * Your Name * Send To * Enter multiple addresses on separate lines or separate them with commas. Message Subject (Your Name) has forwarded a page to you from bioRxiv Message Body (Your Name) thought you would like to see this page from the bioRxiv website.
No Chapter 15 Recognition Absent Qualifying “Foreign Proceeding”
On December 5, 2022, in In re Global Cord Blood Corp., 2022 WL 17478530 (Bankr. S.D.N.Y. Dec.
Restructuring Department Bulletin - August 2022
USA August 15 2022 In the latest issue of the Restructuring Department Bulletin, we highlight recent decisions impacting the restructuring arena, including an order in the Southern District of New York finding that U.S. bankruptcy courts overseeing Chapter 15 cases may recognize and enforce foreign court-sanctioned restructurings that discharge New York Law-governed debt; a Fifth Circuit holding that a debtor may reject regulated energy contracts in spite of FERC regulatory disapproval; and a...
Practical and concise synthesis of nucleoside analogs - Nature Protocols
Abstract Nucleoside analogs are valuable commodities in the development of antisense oligonucleotides or as stand-alone antiviral and anticancer therapies. Syntheses of nucleoside analogs are typically challenged by a reliance on chiral pool starting materials and inefficient synthetic routes that are not readily amenable to diversification.
Tenth Circuit Deepens Circuit Split over Constitutionality of Fee Increases for United States Trustee Program
On October 5, 2021, the Tenth Circuit joined the Second Circuit in concluding statutory fee increases that applied only to debtors filing for bankruptcy in judicial districts administered by the United States Trustee Program (the “US Trustee” or the “UST Program”) violated the U.S. Constitution’s requirement for “uniform” bankruptcy laws.[1] This ruling exacerbates a burgeoning circuit split, as both the Fourth and the Fifth Circuits had previously rejected similar constitutional...
Probiotics and the Microbiome: How can we help patients make sense of probiotics?
This paper is only available as a PDF. To read, Please Download here. Abstract The notion of probiotics as microbes that confer health benefits has its origins in the speculative ideas that are more than a century old, yet remain largely unsubstantiated by scientific evidence. The recent advances in microbiome science have highlighted the importance of intestinal microbes in human physiology and disease pathogenesis.
Probiotics: promise, evidence, and hope
AGA Clinical Practice Guidelines on the Role of Probiotics in the Management of Gastrointestinal Disorders
Avoiding the Pitfalls of Customer Participation
Avoiding the Pitfalls of Customer Participation Frontiers, Leadership, Marketing, Teamwork, Customer Service, Quality & Service When front-line employees feel torn between representing the customer and what they believe is reasonable, they need to know the company has their back. advertisement MIT SMR Frontiers This article is part of an MIT SMR initiative exploring how technology is reshaping the practice of management.
A counterintuitive stereochemical outcome from a chelation-controlled vinymetal aldehyde addition leads to the configurational reassignment of phormidolide A
A counterintuitive stereochemical outcome from a chelation-controlled vinymetal aldehyde addition leads to the configurational reassignment of phormidolide A As part of our ongoing studies towards the total synthesis of phormidolide A (1), we explored the chelation-controlled vinylmetal addition of fragment 2 to aldehyde 3 to install the reported 17S configuration.
Base-Catalyzed Transesterification of Thionoesters
Josiah J. Newton†‡, Robert Britton†, and Chadron M. Friesen*‡ † Department of Chemistry, Simon Fraser University, Burnaby, British Columbia V5A 1S6 , Canada ‡ Department of Chemistry, Trinity Western University, Langley, British Columbia V2Y 1Y1 , Canada J. Org. Chem., 2018, 83 (20), pp 12784–12792 DOI: 10.1021/acs.joc.8b02260 Publication Date (Web): September 20, 2018 Copyright © 2018 American Chemical Society *E-mail: chad.friesen@twu.ca. Cite this:J. Org.
Site‐Selective, Late‐Stage C‐H 18F‐Fluorination on Unprotected Peptides for Positron Emission Tomography Imaging
As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re‐organized for online delivery, but are not copy‐edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors.
U.S. must not allow the Gulf carriers to continue their subsidy-fueled expansion
Thank you for calling attention to the threat that the Gulf airlines’ unfair practices pose to Minnesota jobs in “The not-so-friendly skies.” Although the article accurately summarizes this threat, I would like to refute author Sam Brodey’s assertion that airline consolidation has caused higher fares.In fact, fares decreased significantly following airline deregulation in 1978.
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