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Articles by Robert Chilton
Ketamine in insulin resistance: Pharmacokinetics, cardiovascular implications and cellular effects on cardiomyocytes
CONFLICT OF INTEREST STATEMENT The authors declare no conflicts of interest. REFERENCES 1, , . Ketamine: NMDA receptors and beyond. J Neurosci. 2016; 36(4): 11158-11164. doi:10.1523/JNEUROSCI.1547-16.2016 2, , , et al. The ketogenic diet does not improve cardiac function and blunts glucose oxidation in ischemic heart failure. Cardiovasc Res. 2024; 120(10): 1126-1137. doi:10.1093/cvr/cvae092 3, , , , . Unraveling interactions between anesthetics and the endothelium: update and novel insights. Anesth Analg.
Deciphering the connection: Diabetes, pericyte dysfunction, and their impact on cardiovascular health
In the intricate tapestry of human biology, diabetes mellitus silently threads its way, casting unseen webs across the expanse of global health.1 This enduring metabolic disorder, characterized by elevated blood glucose levels, poses a challenge that extends beyond its well-documented impact on blood vessels. Unbeknownst to many, diabetes conducts a symphony of disruption, particularly affecting the custodians of vascular harmony – the pericytes.
Cap Journal - Housing
Columbus has seen boom times recently – at least for some. Population in Columbus has exploded in the last two decades – and it’s not expected to stop anytime soon. Given the enormous investments by Intel and other major companies, the Mid-Ohio Regional Planning Commission expects about 726,000 new residents in the region by 2050. But that has not spelled good times for all. The influx of people has not been met with an equal influx of new housing options, particularly for people of limited means.
More people in Ohio not met with equal housing opportunities
By Robert “Bo” Chilton Columbus has seen boom times recently – at least for some. Population in Columbus has exploded in the last two decades – and it’s not expected to stop anytime soon. Given the enormous investments by Intel and other major companies, the Mid-Ohio Regional Planning Commission expects about 726,000 new residents in the region by 2050. But that has not spelled good times for all.
Beyond the myocardium: Sodium‐glucose co‐transporter‐2 inhibitors in heart failure
This letter considers how recently postulated mechanisms of action of sodium‐glucose co‐transporter‐2 (SGLT2) inhibitors might contribute to the observed risk reduction in cardiovascular (CV) mortality and hospitalization for heart failure (HF), as reported in CV outcomes trials in patients with and without type 2 diabetes mellitus (T2DM)1-6; namely, stimulation of haematocrit/erythropoietin (EPO)7-9 and sympatho‐inhibition.10-12 The issue of HF in T2DM has become a rapidly evolving concern,...
A New Perspective on Lowering CV Risk From Hypoglycemia
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Effects of Sodium‐Glucose Cotransporter‐2 Inhibitors on the Cardiovascular and Renal Complications of Type 2 Diabetes - Chilton - - Diabetes, Obesity and Metabolism - Wiley Online Library
REVIEW ARTICLE Effects of Sodium‐Glucose Cotransporter‐2 Inhibitors on the Cardiovascular and Renal Complications of Type 2 Diabetes Robert J. Chilton DO, FACC, FAHA Corresponding Author E-mail address: chilton@uthscsa.edu https://orcid.org/0000-0003-0195-5063 Division of Cardiology, University of Texas Health Science Center, San Antonio, Texas, USA Correspondence Robert J.
PCSK9 inhibitors and diabetes: translational biology to clinical practice
Improving patient care incorporates well done translational science with excellent clinical trials. The development of new medications beyond statins to reduce low‐density lipoprotein (LDL) in patients who are at high risk for cardiovascular (CV) events has ushered in new concerns by physicians from recent clinical trials. This article is protected by copyright. All rights reserved.
In emerging area of ‘diabetic lung disease,’ pioglitazone may play preventive role
PHILADELPHIA — Pulmonary arterial hypertension is a growing problem in the setting of insulin resistance and type 2 diabetes, and pioglitazone may serve as a tool to prevent or delay the disease course, according to a speaker here. Right ventricular heart failure is the leading cause of death in pulmonary arterial hypertension, and insulin resistance — with or without type 2 diabetes — worsens endothelial function and, as a result, pulmonary vascular resistance, according to Robert J.
Practical strategies for improving outcomes in T2DM: The potential role of pioglitazone and DPP4 inhibitors
T2DM is a complex disease underlined by multiple pathogenic defects responsible for the development and progression of hyperglycaemia. Each of these factors can now be tackled in a more targeted manner thanks to glucose‐lowering drugs that have been made available in the past 2 to 3 decades.
Practical Strategies for Improving Outcomes in T2DM: the potential role of pioglitazone and DPP4 inhibitors
T2DM is a complex disease recognizing multiple pathogenic defects responsible for the development and progression of hyperglycemia. Each of these factors can now be tackled in a more targeted manner thanks to glucose-lowering drugs made available in the past two to three decades. Recognition of the multiplicity of the mechanisms underlying hyperglycemia calls for treatments addressing more than one these mechanisms with more emphasis placed on the earlier use of combination therapies.
Erratum. Cardiovascular Disease and Type 2 Diabetes: Has the Dawn of a New Era Arrived? Diabetes Care 2017;40:813-820
Erratum. Cardiovascular Disease and Type 2 Diabetes: Has the Dawn of a New Era Arrived? Diabetes Care 2017;40:813–820 Muhammad Abdul-Ghani, Ralph A. DeFronzo, Stefano Del Prato, Robert Chilton, Rajvir Singh, Robert E.J. Ryder Diabetes Care Nov 2017, 40 (11) 1606; DOI: 10.2337/dc17-er11
Cardiovascular Disease and Type 2 Diabetes: Has the Dawn of a New Era Arrived?
Cardiovascular Disease and Type 2 Diabetes: Has the Dawn of a New Era Arrived? Muhammad Abdul-Ghani, Ralph A. DeFronzo, Stefano Del Prato, Robert Chilton, Rajvir Singh, Robert E.J. Ryder Diabetes Care Jul 2017, 40 (7) 813-820; DOI: 10.2337/dc16-2736
Glucose Control and Cardiovascular Outcomes in Clinical Trials of Sodium Glucose Co-transporter 2 Inhibitor Treatments in Type 2 Diabetes
Diabetes imposes a substantial burden on societies worldwide: approximately 25 million individuals in the US have diabetes, of which more than 95 % is type 2.1 Furthermore, its incidence is increasing, a further 79 million adults in the US have pre-diabetes and one in three US adults could have diabetes by 2050.1 In addition, the age of diagnosis of type 2 diabetes is decreasing.2 Lifestyle interventions remain essential to the management of type 2 diabetes; however, most patients will not...
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SGLT2 Inhibitors and Cardiovascular Risk: Lessons Learned From the EMPA-REG OUTCOME Study
Although cardiovascular (CV) mortality is the principal cause of death in individuals with type 2 diabetes (T2DM), reduction of plasma glucose concentration has little effect on CV disease (CVD) risk. Thus, novel strategies to reduce CVD risk in T2DM patients are needed.
Dubai Mall hosts Damien Hirst Stormtrooper art work
One of cinema’s most iconic costume pieces has been given a makeover by artists for a new Dubai exhibition. Artists including the British visionary Damien Hirst have put their personal stamp on the Stormtrooper helmet from the Star Wars movies. Hirst covered the helmet with his trademark coloured spots for the Art Wars exhibition which first appeared at London’s Saatchi Gallery in October 2013.
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