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Robert Chunhua

As seen in: Oxford University Press (OUP), Frontiers, Biomed Central (BMC), Journal of Biomedical Science
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Articles by Robert Chunhua

A novel human specific lncRNA MEK6-AS1 regulates adipogenesis and fatty acid biosynthesis by stabilizing MEK6 mRNA - Journal of Biomedical Science

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By Robert Chunhua, Clinical Biobank
| link.springer.com
Abstract Obesity is becoming one of the major non-communicable diseases with increasing incidence and risks that cannot be ignored. However effective and safe clinical treatment strategies still need to be deeply explored. Increased number and volume of adipocytes lead to overweight and obesity.
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LINC00606 promotes glioblastoma progression through sponge miR-486-3p and interaction with ATP11B - Journal of Experimental & Clinical Cancer Research

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By Robert Chunhua
| link.springer.com
Abstract LncRNAs regulate tumorigenesis and development in a variety of cancers. We substantiate for the first time that LINC00606 is considerably expressed in glioblastoma (GBM) patient specimens and is linked with adverse prognosis. This suggests that LINC00606 may have the potential to regulate glioma genesis and progression, and that the biological functions and molecular mechanisms of LINC00606 in GBM remain largely unknown.
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RGS20 promotes non-small cell lung carcinoma proliferation via autophagy activation and inhibition of the PKA-Hippo signaling pathway - Cancer Cell International

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By Robert Chunhua
| Biomed Central (BMC)
References Chen Z, Fillmore CM, Hammerman PS, Kim CF, Wong KK. Non-small-cell lung cancers: a heterogeneous set of diseases. Nat Rev Cancer. 2014;14(8):535–46. CAS PubMed PubMed Central Google Scholar Siegel RL, Miller KD, Jemal A. Cancer statistics, 2016. CA Cancer J Clin. 2016;66(1):7–30. PubMed Google Scholar Guo H, Zhang J, Qin C, Yan H, Liu T, Hu H et al. Biomarker-targeted therapies in non-small cell lung cancer: current status and perspectives. Cells. 2022;11(20).
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S-adenosyl-L-methionine alleviates the senescence of MSCs through the PI3K/AKT/FOXO3a signaling pathway

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By Kuiwen District, Robert Chunhua, Guangwen road
| Oxford University Press (OUP)
Cellular senescence significantly affects the proliferative and differentiation capacities of mesenchymal stem cells (MSCs). Identifying key regulators of senescence and exploring potential intervention strategies, including drug-based approaches, are active areas of research. In this context, S-adenosyl-L-methionine (SAM), a critical intermediate in sulfur amino acid metabolism, emerges as a promising candidate for mitigating MSC senescence.
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Comprehensive transcript-level analysis reveals transcriptional reprogramming during the progression of Alzheimer’s disease

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By Robert Chunhua, Stephen Ginsberg, Sriram Balusu, Larissa Traxler
| Frontiers
Hao Wu1†, Jiao Wang1†, Xiaoyuan Hu2, Cheng Zhuang1, Jianxin Zhou1, Peiru Wu1, Shengli Li3* and Robert Chunhua Zhao1,4* 1Laboratory of Molecular Neural Biology, School of Life Sciences, Shanghai University, Shanghai, China 2H.
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Comprehensive transcript-level analysis reveals transcriptional reprogramming during the progression of Alzheimer's disease

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By Shanghai Municipality, Shanghai Jiao Tong, Robert Chunhua
| Frontiers
Hao Wu1, Jiao Wang1, Zhuang Cheng1, Jianxin Zhou1, Peiru Wu1, Shengli Li2* and Robert Chunhua Zhao1, 3 1Shanghai University, China 2School of Medicine, Shanghai Jiao Tong University, China 3Chinese Academy of Medical Sciences and Peking Union Medical College, China The final, formatted version of the article will be published soon. Receive an email when it is updated Alzheimer's disease (AD) is a common neurodegenerative disorder that has a multi-step disease progression.
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Irisin mediates beiging of adipose-derived mesenchymal stem cells through binding to TRPC3 - BMC Biology

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By Robert Chunhua
| Biomed Central (BMC)
References Wu W, Shi F, Liu D, Ceddia RP, Gaffin R, Wei W, et al. Enhancing natriuretic peptide signaling in adipose tissue, but not in muscle, protects against diet-induced obesity and insulin resistance. Sci Signal. 2017;10(489):eaam6870. Kahn SE, Hull RL, Utzschneider KM. Mechanisms linking obesity to insulin resistance and type 2 diabetes. Nature. 2006;444(7121):840–6. CAS PubMed Article Google Scholar Lepor NE, Fouchia DD, McCullough PA.
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