Robert Coffman

Significance Integrin αIIbβ3 is crucial for platelet aggregation and blood clotting, yet the molecular mechanisms behind its activation remain largely unknown. Although Mn2+ enhances integrin’s ability to bind ligands, the exact process at the molecular level is still unclear. In this study, we used molecular simulations to compare how Mn2+ influences the molecular rearrangements of αIIbβ3, relative to Mg2+/Ca2+.

Abstract The adhesion protein integrin is a transmembrane heterodimer that plays a pivotal role in cellular processes such as cell signaling and cell migration. To execute its function, integrin undergoes extensive conformational changes from a bent-closed to an extended-open state. Resolving the structures across these changes remains a challenge with both experimental and computational methods, but is crucial for understanding the activation mechanism of integrin.

ABSTRACT HIV-related stigma and medical mistrust are significant challenges to addressing HIV inequities among gay, bisexual, and other men who have sex with men (MSM). HIV-related stigma is associated with high levels of medical mistrust, but there is limited knowledge regarding the mechanisms that link these variables.