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Articles by Robert Coukos
Lysosomal dysfunction in neurodegenerative disease
Abstract Examination of genetic risk factors associated with neurodegenerative diseases has provided important mechanistic insights into the pathophysiology of these disorders, and it has implicated defects in lysosomal function as a key component of the neurodegenerative process. The lysosome has a primary role in mediating degradation of both intracellular contents and endocytosed material from the extracellular space.
Key genes and convergent pathogenic mechanisms in Parkinson disease - Nature Reviews Neuroscience
Abstract Parkinson disease (PD) is a neurodegenerative disorder marked by the preferential dysfunction and death of dopaminergic neurons in the substantia nigra. The onset and progression of PD is influenced by a diversity of genetic variants, many of which lack functional characterization.
Opinion & Special Articles: Examining the Hidden Curriculum of Medical School From a First-Generation Student Perspective
Abstract With the incorporation of pass/fail outcomes into the curricula of many medical schools, a greater premium is being placed on leadership, research, and other extracurricular pursuits. These activities, as well as the cultivation of social capital, represent a “hidden curriculum” which offers significant benefits to career development that are not often explicitly stated.
Opinion & Special Articles: Examining the Hidden Curriculum of Medical School From a First-Generation Student Perspective
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Dysregulation of organelle membrane contact sites in neurological diseases
Abe K. Ohno Y. Sassa T. Taguchi R. Çalışkan M. Ober C. Kihara A. Mutation for nonsyndromic mental retardation in the trans-2-enoyl-CoA reductase TER gene involved in fatty acid elongation impairs the enzyme activity and stability, leading to change in sphingolipid profile. J. Biol. Chem. 2013; 288: 36741-36749https://doi.org/10.1074/jbc.M113.493221 Abu-Remaileh M. Wyant G.A. Kim C. Laqtom N.N. Abbasi M. Chan S.H. Freinkman E.
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