Robert Fick

1. Introduction Determining the hydrogen bonding (H-bonding) status of individual bonds in nucleic acids is key to understanding their structure, dynamics, and biological functions. This includes recognition by proteins, localized melting required for transcription and replication of DNA, and determining how specific sequences can be targeted with drugs. H-bonds are also critical for determining the complex tertiary structures formed by RNA.

The reaction following Washington Capitals coach Barry Trotz's resignation on Monday is twofold – why and who's the next coach?Indeed, it won't be long before Trotz is in the rearview mirror of smiling fans. Hey, great job, thanks for winning the Stanley Cup and good luck in future endeavors. But if anything is true in Washington, there's a short attention span for the past and a lust for the future.Maybe Caps owner Ted Leonsis was too cheap to pay Trotz the money he deserved.

Barry Trotz has announced his resignation as head coach of the Washington Capitals, 11 days after winning the Stanley Cup.The 55-year-old coach entered the 2017-18 NHL season on the final year of a four-year contract, and had hopes of negotiating a new deal after leading the Caps to the first Stanley Cup championship in the organization's 44-year history.