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Articles by Robert Galinsky
Rapid oxygen titration following cardiopulmonary resuscitation mitigates cerebral overperfusion and striatal mitochondrial dysfunction in asphyxiated newborn lambs - Shiraz Badurdeen, Robert Galinsky, Calum T Roberts, Kelly J Crossley, Valerie A Zahra, Al
Introduction Cardiopulmonary resuscitation (CPR) of neonates with severe perinatal asphyxia currently focuses on rapid restoration of the circulation to limit ongoing hypoxic-ischemic brain injury.1,2 Given the challenges in conducting adequately powered trials of CPR in neonates, international recommendations rely on transitional animal models to guide practice.1 Current guidelines recommend increasing the fraction of inspired oxygen (FiO2) to 100% if chest compressions are required to...
Rapid oxygen titration following cardiopulmonary resuscitation mitigates cerebral overperfusion and striatal mitochondrial dysfunction in asphyxiated newborn lambs
Abstract Asphyxiated neonates must have oxygenation rapidly restored to limit ongoing hypoxic-ischemic injury. However, the effects of transient hyperoxia after return of spontaneous circulation (ROSC) are poorly understood. We randomly allocated acutely asphyxiated, near-term lambs to cardiopulmonary resuscitation in 100% oxygen (standard oxygen, n=8) or air (n=7) until 5 minutes after ROSC, or to resuscitation in 100% oxygen immediately weaned to air upon ROSC (rapid-wean, n=7).
Creatine Metabolism in Female Reproduction, Pregnancy and Newborn Health
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Protective effects of delayed intraventricular TLR7 agonist administration on cerebral white and gray matter following asphyxia in the preterm fetal sheep
Abstract Preterm brain injury is highly associated with inflammation, which is likely related in part to sterile responses to hypoxia-ischemia. We have recently shown that neuroprotection with inflammatory pre-conditioning in the immature brain is associated with induction of toll-like receptor 7 (TLR7).
Complex interactions between hypoxia-ischemia and inflammation in preterm brain injury
Children surviving preterm birth have a high risk of disability, particularly cognitive and learning problems. There is extensive clinical and experimental evidence that disability is now primarily related to dysmaturation of white and gray matter, defined by failure of oligodendrocyte maturation and neuronal dendritic arborization, rather than cell death alone. The etiology of this dysmaturation is multifactorial, with contributions from hypoxia-ischemia, infection/inflammation and barotrauma.
Creative Cocktails That Everyone Needs To Drink This Fall
Cocktail etiquette in New York City has a long standing history defined by some classic drinks and yet, it is an ever evolving art form that draws clients and customers who don’t tolerate close minded and self satisfied bartenders.
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