Research Article Lacey J. Favazzo, Ann Lindley Gill, Christopher W. Farnsworth, Robert A. Mooney, Steven R. Gill Michael J. Federle, Editor DOI: 10.1128/JB.00107-19 ABSTRACT Staphylococcus aureus causes a wide spectrum of disease, with the site and severity of infection dependent on virulence traits encoded within genetically distinct clonal complexes (CCs) and bacterial responses to host innate immunity. The production of nitric oxide (NO) by activated phagocytes is a major host response to which S.