Robert Roger

Abstract Computed tomography (CT)-based subject-specific finite element (SS-FE) models offer a quantitative approach to assessing the stability of metastatic vertebrae. A critical step in developing SS-FE models is image segmentation, however automatic techniques fail to accurately capture the altered contours of metastatic vertebrae, making manual image segmentation the preferred approach.

Participants This study describes 47 affected individuals from 29 families. We describe 26 newly identified individuals from 22 families (families F1-17, F23, F24, F26, F27, and F29) accrued through professional communication as well as through GeneMatcher [19]. They were recruited from hospitals or clinics from the USA and other countries including the UK, Germany, Italy, France, The Netherlands, Canada, and Singapore.