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Articles by Robert Thänert
Gut microbiome evolution from infancy to 8 years of age - Nature Medicine
Abstract The human gut microbiome is most dynamic in early life. Although sweeping changes in taxonomic architecture are well described, it remains unknown how, and to what extent, individual strains colonize and persist and how selective pressures define their genomic architecture.
Clinical sequelae of gut microbiome development and disruption in hospitalized preterm infants
In Figure 1D of the originally published article, diamonds indicating the number of preterm infants with metagenomically detected species forandwere incorrect. The article has been updated online and the correct version appears in print. The authors regret the error.
Clinical sequelae of gut microbiome development and disruption in hospitalized preterm infants
Highlights • Antibiotics and non-antibiotic drugs govern infant gut microbiome development • Antibiotic-associated microbial shifts introduce pathogens and resistance • Hospitalized preterm infants share isogenic C. difficile and S. epidermidis • Microbial development stagnates before late-onset necrotizing enterocolitis Summary Aberrant preterm infant gut microbiota assembly predisposes to early-life disorders and persistent health problems.
Gut microbiome correlates of recurrent urinary tract infection: a longitudinal, multi-center study
Keywords Gut microbiome Recurrent urinary tract infection Antimicrobial resistance Escherichia coli Evidence before this study We searched PubMed for the terms “recurrent urinary tract infection” (rUTI) AND “microbiome” AND “longitudinal” with no language restrictions from database inception to December 19, 2023. Of the 6 search results, only 1 study from 2022 sequenced the gut microbiome, comparing 15 women with rUTI with 16 healthy controls.
The resistance within: Antibiotic disruption of the gut microbiome and resistome dynamics in infancy
• None Persistence of birth mode-dependent effects on gut microbiome composition, immune system stimulation and antimicrobial resistance during the first year of life. : • None The association between antibiotics in the first year of life and child growth trajectory. : • None Maturation of the gut microbiome during the first year of life contributes to the protective farm effect on childhood asthma.
Persisting uropathogenic Escherichia coli lineages show signatures of niche-specific within-host adaptation mediated by mobile genetic elements
Antipov D. Hartwick N. Shen M. Raiko M. Lapidus A. Pevzner P.A. plasmidSPAdes: assembling plasmids from whole genome sequencing data. Bioinformatics. 2016; 32: 3380-3387 Arndt D. Grant J.R. Marcu A. Sajed T. Pon A. Liang Y. Wishart D.S. PHASTER: a better, faster version of the PHAST phage search tool. Nucleic Acids Res. 2016; 44: W16-W21 Bankevich A. Nurk S. Antipov D. Gurevich A.A. Dvorkin M. Kulikov A.S. Lesin V.M. Nikolenko S.I. Pham S. Prjibelski A.D. et al.
Comparative Genomics of Antibiotic-Resistant Uropathogens Implicates Three Routes for Recurrence of Urinary Tract Infections
Research Article | Clinical Science and Epidemiology Robert Thänert, Kimberly A. Reske, Tiffany Hink, Meghan A. Wallace, Bin Wang, Drew J. Schwartz, Sondra Seiler, Candice Cass, Carey-Ann D. Burnham, Erik R. Dubberke, Jennie H.
Host-inherent variability influences the transcriptional response of Staphylococcus aureus during in vivo infection
For this study, we selected two strains of mice that differ in their susceptibility to S. aureus infection16,17. Whereas A/J mice are very vulnerable to S. aureus, resulting in a significantly increased bacterial growth in the kidneys (Fig. 1a) and liver (Fig. 1b) and fatal infection outcome (Fig. 1c), C57BL/6 mice exhibit greater resistance to S. aureus and were capable to significantly restrict bacterial growth in the kidneys (Fig. 1a) and liver (Fig. 1b) with all mice surviving (Fig. 1c).
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