Roberta Eufrasia Ledda

Introduction Lung cancer screening (LCS) with low-dose computed tomography (LDCT) reduces mortality in heavy smokers by enabling early identification of lung cancers (LCs) otherwise diagnosed as symptomatic advanced disease [1–6]. Nevertheless, LCS might lead to the diagnosis and treatment of lesions that would not affect prognosis, thus exposing volunteers to unnecessary risks of intervention, such as those related to biopsy procedures or excision [7–10].

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