Computational Approach to Predict Metabolic Alterations Due to Single-Enzyme Defect in Hepatocytes Histidine and Histamine Are Reduced in PH1 Alanine Reduces Histamine Levels in WT Mice while GPT Overexpression Restores Normal Histamine Levels and Reduces Urinary Oxalate in PH1 Mice Extension and Analysis of the Genome-Scale Metabolic Model of Hepatocytes for PH1 Mammalian intermediary metabolism was defined several years ago in biochemical terms from in vitro studies, but we are still...
