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Rocio Montes de Oca on Muck Rack

Rocio Montes de Oca

As seen in: Nature
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Ciltacabtagene autoleucel in high-risk smoldering multiple myeloma: the CAR-PRISM phase 2 trial

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By Omar Nadeem, Sarah Nikiforow, Elizabeth O’Donnell, Robert A. Redd, Adam S. Sperling, Yuxin Liu, Frances Arters, Colin A. O’Donnell, Marjorie Marto, Amy E. Bergeron, Kristin McHugh Verified, Abigail M. Caron, Elizabeth A. Grimm, Francesco Corrado, Kevin Panaro, Eric Smith Verified, Kenneth Anderson, Caron A Jacobson, Nikhil C. Munshi, Paul Richardson Verified, Deepu Madduri, Jordan M. Schecter, Craig Tendler, Lorenzo Trippa, Maria Mateos Verified, Jerome Ritz, Irene M. Ghobrial, Anna Bosch-Vilaseca, Kevin C. DeBraganca, Caleb McEntire, Brendan Kineavy, Emilie Swenson, Quentin Berry, Hope Wei, Emily Durlacher, Nayda Bidikian, Rocio Montes de Oca, Tamar Lengil, Denise De Wiest, Casey Gervais, Mark A. Wildgust
| Nature Verified
Abstract High-risk smoldering multiple myeloma (HR-SMM) carries an increased risk of progression to multiple myeloma, making it an ideal setting to test whether chimeric antigen receptor (CAR) T cell therapy can achieve curative outcomes. Here in this phase 2 study, patients with HR-SMM received ciltacabtagene autoleucel (cilta-cel) at 0.3–0.5 × 106 or >0.5 × 106 viable CAR+ T cells per kilogram without induction or bridging therapy. Patients with >40% marrow involvement were excluded.
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