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Roddy O’Donnell

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Intracranial Pressure Signal Is Not a Treatment Threshold in Pediatric Traumatic Brain Injury—Reply

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By Shruti Agrawal, Peter Hutchinson Verified, Roddy O’Donnell
| JAMA Network Verified
In Reply Intracranial pressure (ICP) signals are relevant to physiology-informed treatment in pediatric traumatic brain injury (pTBI). We thank Song et al for their thoughtful comments on our study1 and broadly accept the distinction between prognostic and treatment thresholds; however, several aspects merit clarification. In making this distinction, it is important not to obscure the central question: when does clinically meaningful cumulative secondary injury begin?
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