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Roderick E. Hubbard on Muck Rack

Roderick E. Hubbard

As seen in: British Journal of Cancer
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Articles

Reducing Attrition via Improved Strategies for Pre-clinical Drug Discovery : SPR-biosensor Aided Interaction Studies

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By Helena Danielson, Roderick E. Hubbard, Uppsala universitet
| avhandlingar.se
Nyckelord: NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Biokemi; Biochemistry; Sammanfattning: The efficacy of a drug is tightly intertwined with its interaction mechanism with the drug target. The mechanism is dependent on the physicochemical and structural characteristics of both target and drug molecule.Drug discovery is plagued by a high attrition rate, whereas in the clinic, a major issue is drug resistance.
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Twenty years on: the impact of fragments on drug discovery

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By Daniel A. Erlanson, Stephen W. Fesik, Roderick E. Hubbard, Wolfgang Jahnke, Harren Jhoti
| British Journal of Cancer Verified
After 20 years of sometimes quiet growth, fragment-based drug discovery (FBDD) has become mainstream. More than 30 drug candidates derived from fragments have entered the clinic, with two approved and several more in advanced trials. FBDD has been widely applied in both academia and industry, as evidenced by the large number of papers from universities, non-profit research institutions, biotechnology companies and pharmaceutical companies.
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