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Rodolpho do Aido-Machado on Muck Rack

Rodolpho do Aido-Machado

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Articles

Molecular basis for the regulation of the SUMOylation activity of the Smc5/6 complex by Esc2

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By Helena Borràs-Gas, Roger Solé-Soler, Michael Williamson, Nathalia Varejão, David Reverter, Rodolpho do Aido-Machado, Martina Matas, Jordi Torres-Rosell
| Nature Verified
Abstract Post-translational modification by SUMO regulates a wide array of cellular processes. Despite the large number of SUMOylated substrates, only a limited set of SUMO E3 ligases have been identified, raising important questions about how substrate specificity is achieved. In budding yeast, the nuclear protein Esc2 functions as a cofactor in the SUMO pathway through its interaction with the E2 enzyme Ubc9.
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