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Roger Barker

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Articles

Three-dimensional cell-cell interactions promote direct reprogramming of patient fibroblasts into functional and transplantable neurons

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By Brandon M. Genco, Yanni Schneider, Janko Kajtez, Kerstin Laurin, Fredrik Nilsson, Andreas Bruzelius, Efrain Cepeda-Prado, Marcella Birtele, Roger Barker, Freja Herborg, Daniella Rylander Ottosson, Alessandro Fiorenzano, Mette Habekost, Malin Parmar
| Science Magazine Verified
Abstract Direct reprogramming of somatic cells into induced neurons (iNs) has become an attractive strategy for the generation of patient-specific neurons for disease modeling and regenerative neuroscience. To this end, adult human dermal fibroblasts (hDFs) present one of the most relevant cell sources.
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