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Rokas Dargis

As seen in: BioRxiv
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Articles

Regulation of Ordinal DNA Translocation Cycle in Bacteriophage φ29 through Trans-Subunit Interactions

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By Joshua Pajak, Marc C. Morais, Rokas Dargis, Pavan Ariyawansa
| BioRxiv
Abstract Certain viruses such as tailed bacteriophages and herpes simplex virus package double-stranded DNA into empty procapsids via powerful, ring-shaped molecular motors. High resolution structures and force measurements on the DNA packaging motor of bacteriophage φ29 revealed that its five ATPase subunits coordinate ATP hydrolysis with each other to maintain the proper cyclic sequence of DNA translocation steps about the ring.
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