Rom Mendel

We see them in the emergency room: people who were going about their normal lives just moments earlier and suddenly cannot speak clearly, move an arm or stand on their feet. From the moment they arrive at the hospital, a race against time begins. Every minute that a blood vessel in the brain remains blocked, millions of nerve cells can suffer irreversible damage. For years, the medication used to dissolve these clots has required an intravenous infusion lasting about an hour.

Abstract Objective MS is a demyelinating CNS disorder with a spectrum of clinical patterns regarding course and prognosis. Although several prognostic factors are considered in the initial evaluation of patients, biological markers defining the disease course and guiding treatments are currently lacking. It is unknown whether patients with CSF pleocytosis differ in regard to symptoms, disease course, and prognosis from those without.