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Microbubble Shell Stiffness Engineering Enhances Ultrasound Imaging, Drug Delivery, and Sonoporation
1 Introduction Microbubbles (MB) are gas-filled particles that are routinely used in the clinic for ultrasound (US) imaging and therapy.[1, 2] Due to their size of 1–8 µm, MB are confined within blood vessels and do not extravasate into tissues.
Polymeric antibubbles with strong ultrasound imaging capabilities
Polymeric antibubbles with strong ultrasound imaging capabilities† Antibubbles are liquid droplets encapsulated by a gas film that have recently been explored for on-demand ultrasound-triggered drug release. However, their ultrasound imaging capabilities are limited by their stiff shells stabilized with silica nanoparticles.
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