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Abstract Astrocytes control brain activity via both metabolic processes and gliotransmission, but the physiological links between these functions are scantly known. Here we show that endogenous activation of astrocyte type-1 cannabinoid (CB1) receptors determines a shift of glycolysis towards the lactate-dependent production of d-serine, thereby gating synaptic and cognitive functions in male mice.
Highlights • ER/mitochondria contacts in astrocytes are determinants of synaptic integration • Mitochondrial calcium uptake is actively modulated by mtCB1 • Mitochondria-dependent calcium dynamics in astrocytes determine synaptic activity • Astroglial mtCB1 receptors are required for lateral synaptic plasticity Summary Intracellular calcium signaling underlies the astroglial control of synaptic transmission and plasticity.
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