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Romina Barria on Muck Rack

Romina Barria

As seen in: BioRxiv
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Articles

An Ionic Sensor acts in Parallel to dSarm to Promote Neurodegeneration

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By Adel Avetisyan, Romina Barria, Amy H Sheehan, Marc Freeman
| BioRxiv
Abstract How neurons to sense when they are terminally dysfunctional and activate neurodegeneration remains poorly defined. The pro-degenerative NAD+ hydrolase dSarm/SARM1 can act as a metabolic sensor by detecting pathological changes in NAD+/NMN and subsequently induce catastrophic axon degeneration.
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Drosophila with-no-lysine and frayed Act in Parallel to dSarm to Drive Neurodegeneration Following dNmnat Depletion

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By Amy H Sheehan, Marc Freeman, Adel Avetisyan, Romina Barria
| BioRxiv
Abstract The maintenance of neuronal circuits is vital for sustaining nervous system function throughout life. Neurons are particularly susceptible to damage from metabolic and environmental stressors, which can lead to various neurodegenerative diseases. Over the past three decades, research has identified critical neuronal survival factors like Nmnat2 and key drivers of axon destruction, such as Sarm1, following neuronal injury.
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