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Romualdo Barroso Sousa on Muck Rack

Romualdo Barroso Sousa

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Tumor genomics in patients younger than 40 years of age with metastatic breast cancer - npj Precision Oncology

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By Kristen D. Brantley, Gregory Kirkner, Melissa Hughes, Yvonne Y. Li, Sarah Strauss, Brittany L. Bychkovsky, Charlotte Tannenbaum, Maggie Loucks, Tari A. King, Bruce Johnson, Lynette M. Sholl, Deborah R. Dillon, Sara M. Tolaney, Andrew D. Cherniack, Ann H. Partridge, Nancy Lin, Ana C. Garrido-Castro, Ananya Kodali, Anne-Marie Feeney, Ayesha Mohammed-Abreu, Romualdo Barroso Sousa, Barbara K. LeStage
| Nature Verified
Abstract Unique disease characteristics of younger patients warrants investigation of tumor genomics in young-onset metastatic breast cancer (MBC). Targeted DNA sequencing was completed for tumors of MBC patients diagnosed between 2009-2020. Multivariable logistic regression tested associations between single nucleotide variants (SNVs) and copy number variants and age at MBC diagnosis. Multivariable Cox regression estimated hazard ratios for overall survival (OS) by somatic alterations.
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