Rona Moni Bora

1 Introduction Quinolines are one of the crucial classes of nitrogen containing heterocyclic compounds that have many applications in pharmaceuticals, material science, and catalysis [1-4]. Quinoline and its derivatives are the key structural framework with several biological applications including antibacterial [5-7], antimalarial [8, 9], anticancer [10, 11], and anti-inflammatory [12] properties, etc. Figure 1 displays a few quinoline-based drugs along with their primary application.

A heterogeneous cobalt-catalyzed synthesis of 4-aryl-2-methyl quinolines from cheap and easily available anilines via C-H bond activation/cyclization in the presence of PEG-400 and TfOH is reported here. The cobalt catalyst was easily prepared and characterized, and PEG-400 served as a carbon source in addition to being a solvent. Easy separation and reusability of the catalyst and reaction medium (PEG-400) make the protocol green and sustainable.

Conflicts of Interest The authors declare no conflicts of interest. Supporting Information Filename Description aoc70218-sup-0001-SuppInformation.docxWord 2007 document , 20.1 MB Data S1. Supporting information. References 1 and , “High-Yield Biocatalytic Amination Reactions in Organic Synthesis,” Current Organic Chemistry 14, no. 17 (2010): 1914–1927, https://doi.org/10.2174/138527210792927546.