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Ronald S. Flannagan on Muck Rack

Ronald S. Flannagan

As seen in: Nature, BioRxiv
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Articles

Discovery of broad-spectrum bacterial polyamine detoxification inhibitors as potential antivirulence agents and antibiotic adjuvants

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By Ronald S. Flannagan, Jonas Wong, Ahmed Soliman, Wael Elhenawy
| BioRxiv
Abstract The alarming rise in antimicrobial resistance reinforces an urgent need for new antimicrobial strategies. Chemicals at infection sites, such as polyamines, often influence microbial virulence and antibiotic response. Polyamines are cationic small molecules overproduced by the host during infection, modulating immune responses - the ability of several pathogens to detoxify polyamines correlated with hypervirulence.
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Discovery of broad-spectrum bacterial polyamine detoxification inhibitors as potential antivirulence agents and antibiotic adjuvants

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By Ronald S. Flannagan, Ahmed Soliman, Wael Elhenawy, Jonas Wong
| BioRxiv
Abstract Bacteria continue to develop resistance against antibiotics, including last-resort ones, reinforcing the urgent need for new antimicrobial strategies. Chemicals at infection sites in the host often influence microbial virulence and antibiotic response; such interactions may offer new antimicrobial targets. Polyamines are cationic small molecules bacteria may encounter at infection sites. They are overproduced during infection, modulating host immune responses.
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De Novo Purine Biosynthesis Is Required for Intracellular Growth of Staphylococcus aureus and for the Hypervirulence Phenotype of a purR Mutant

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By Mariya I. Goncheva, Ronald S. Flannagan, David E. Heinrichs
| asm.org
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions Mariya I. Goncheva, Ronald S. Flannagan, David E. Heinrichs Andreas J. Bäumler, Editor DOI: 10.1128/IAI.00104-20 ABSTRACT Staphylococcus aureus is a noted human and animal pathogen. Despite decades of research on this important bacterium, there are still many unanswered questions regarding the pathogenic mechanisms it uses to infect the mammalian host.
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