Ronewa Nematswerani

1 Introduction Kv7 potassium channels (encoded by KCNQ genes) are key regulators of membrane excitability in neurons and other excitable cells. The heteromeric Kv7.2/7.3 channel complex underlies the neuronal M-current, a slowly activating, non-inactivating potassium conductance that stabilizes the resting membrane potential and limits repetitive firing [1, 2]. Dysfunction of Kv7.2/7.3 channels has been implicated in epilepsy, neuropathic pain, and neurodevelopmental disorders [3-5].

ΔΔCT comparative CT method DMEM Dulbecco's Modified Eagle Medium DOPE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine DPPC phospholipid 1,2-dipalmitoyl-sn-glycero-3-phosphocholine FBS fetal bovine serum HEK-293FT fast-growing subclone of human embryonic kidney cells LDH lactate dehydrogenase PBS Phosphate buffered saline P/S penicillin-streptomycin 1321N1 human astrocytoma cells 1 Introduction The efficient delivery of exogenous genetic material into cells remains a critical challenge in gene...

Lewis acid-catalyzed [2π+2σ] cycloaddition of dihydropyridines with bicyclobutanes Herein we report a simple BF3-catalyzed cycloaddition of dihydropyridines with bicyclobutanes for the expedient synthesis of novel three-dimensional azacycle-fused bicyclo[2.1.1]hexane scaffolds. The reaction utilizes easily accessible starting materials and proceeds under mild, metal-free conditions with high atom efficiency. This article is Open Access This article has not yet been cited.