Rongqing Li

4-HNE 4-hydroxynonenal ActD actinomycin D CHX cycloheximide CQ chloroquine DMSO dimethyl sulfoxide GPX4 glutathione peroxidase 4 HCC hepatocellular carcinoma KEAP1 kelch-like ECH-associated protein 1 MDA malondialdehyd;malondialdehyde NRF2 nuclear factor erythroid 2-related factor 2 OsO₄ osmium tetroxide ROS reactive oxygen species 1 Introduction Hepatocellular carcinoma (HCC) has been acknowledged as the third deadliest contributor to cancer-associated mortalities [1].

Abstract Glioblastoma (GBM) is the most common primary intracranial malignant tumor. Recent literature suggests that induction of programmed death has become a mainstream cancer treatment strategy, with ferroptosis being the most widely studied mode. Complement C5a receptor 1 (C5aR1) is associated with both tumorigenesis and tumor-related immunity. However, knowledge regarding the role of C5aR1 in GBM progression is limited.

Abstract Metabolic reprogramming is a major feature of cancer, and aerobic glycolysis is one of the most widely studied metabolic reprogramming processes. Acidic ribosome protein P2 (RPLP2) is associated with both tumorigenesis and endoplasmic reticulum stress. However, limited knowledge exists regarding the role of RPLP2 in hepatocellular carcinoma (HCC) progression. In the present study, we observed a significant upregulation of RPLP2 in HCC tissues.