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Roosheel Sandeep Patel on Muck Rack

Roosheel Sandeep Patel

As seen in: Nature
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Articles

Low-level Aurora kinase A amplification: CDK4/6 inhibitor resistance biomarker in hormone receptor-positive metastatic breast cancer

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By Seth A. Wander, Emily Schultz, Agnieszka K. Witkiewicz, Georg F. Bischof, Erik S. Knudsen, Karthik V. Giridhar, Lisa D. Eli, Ezgi Karaesmen Rizvi, Roosheel Sandeep Patel
| Nature Verified
Abstract In this large, real-world, translational research cohort of 708 patients in the Tempus database who had hormone receptor-positive (HR+), human epidermal growth factor 2-negative (HER2−) metastatic breast cancer with prior cyclin-dependent kinase 4 and 6 inhibitor (CDK4/6i) exposure, low-level Aurora kinase A (AURKA) copy-number (CN) gain was common, occurring in 106/708 patients (15.0%).
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