Rosa‐Maria Guéant‐Rodriguez

Abstract Background Many arguments suggest that neutrophils could play a prominent role in COVID‐19. However, the role of key components of neutrophil innate immunity in severe forms of COVID‐19 has deserved insufficient attention. We aimed to evaluate the involvement of neutrophil elastase, histone‐DNA, and DNases in systemic and multi‐organ manifestations of COVID‐19.

To the Editor, Convergent arguments suggest that innate immunity related to neutrophils, and in particular neutrophil extracellular traps (NETs), could play a key role in response to SARS‐CoV‐2 infection.1 The neutrophil‐to‐lymphocyte ratio is a predictor of severity.2 Neutrophils are involved in the innate response to pulmonary viral infections.3 The production of NETs (NETosis) is increased by inflammatory mediators and activates macrophages in pulmonary alveoli.3, 4 Despite these...