Rosamaria Lombardo

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Abstract : Clozapine (CZP) is the only effective drug in schizophrenia resistant to typical antipsychotics. However, existing dosage forms (oral or orodispersible tablets, suspensions or intramuscular injection) show challenging limitations. After oral administration, CZP has low bioavailability due to a large first-pass effect, while the i.m. route is often painful, with low patient compliance and requiring specialised personnel. Moreover, CZP has a very low aqueous solubility.

3.2.2. In Vivo Studies Once the in vitro tests have been performed and the formulation to be tested in vivo has been selected, the next step is to select the most appropriate animal according to the disease to be studied. Most of the reviewed studies explore the pathogenesis of ulcerative colitis, the modeling of which can be done by the immune method or by chemical stimulation.