Rosaria Siciliani

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1 INTRODUCTION Patients affected by urea cycle disorders (UCDs), such as type 1 citrullinemia, show various degrees of neurodevelopmental impairment because of the neurological damage induced by hyperammonemia during growth. Those patients may be poor or not cooperative with dental practitioners because of their cognitive deficits. Thus, general anesthesia (GA) is the only way to receive dental treatments for those special needs patients.

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