Roshane Francis

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Gastrointestinal transcription factors drive lineage-specific developmental programs in organ specification and cancer

Dec 11, 2019 |

By Haiyang Guo, Musaddeque Ahmed, Roshane Francis, Catherine Streutker

| Science Magazine

Abstract Transcription factors (TFs) are spatially and temporally regulated during gut organ specification. Although accumulating evidence shows aberrant reactivation of developmental programs in cancer, little is known about how TFs drive lineage specification in development and cancer.

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Gastrointestinal transcription factors drive lineage-specific developmental programs in organ specification and cancer

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