Rosina Savisaar

Results To evaluate whether iPSC-CMs recapitulate the splicing patterns of the heart and determine the developmental stage they most closely resemble, we directed the differentiation of three independent iPSC lines (referred to as D, G, and T; Figure 1A) into cardiomyocytes (see Methods). The majority of differentiated iPSC-CMs exhibited cardiomyocyte-like morphology, including an elongated shape and well-defined sarcomere structures (Figures 1B and 1C).

1,7 1Université Paris-Saclay, CNRS, IRD, UMR Évolution, Génomes, Comportement et Écologie, 91198 Gif-sur-Yvette, France; 2Department of Biological Sciences, University at Albany, State University of New York, Albany, New York 12222, USA; 3Mondego Science, 11000 Carcassonne, France; 4UMR CNRS 7267 Écologie et Biologie des Interactions, Équipe Écologie Évolution Symbiose, Université de Poitiers, 86073 Poitiers, France; 5Laboratoire de Biométrie et Biologie Évolutive, Université de Lyon,...