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Articles by Ross Firestone
Stem cell autograft minimal residual disease negativity and survival outcomes for multiple myeloma autotransplant
Abstract Contemporary induction regimens for newly diagnosed multiple myeloma (NDMM), particularly daratumumab-based quadruplets, achieve high rates of bone marrow (BM) minimal residual disease (MRD) negativity and improve progression-free survival (PFS) and overall survival (OS) after upfront autologous stem cell transplantation (ASCT). However, the incidence and clinical impact of stem cell autograft (AG) contamination with malignant plasma cells in the current treatment era remain undefined.
Impact of granulocyte colony-stimulating factors on cytokine release syndrome during bispecific antibody initiation in relapsed/refractory multiple myeloma
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Abstract Bispecific antibody (BsAb) treatment in multiple myeloma can be associated with adverse events including cytokine release syndrome (CRS), cytopenias, and infections. While granulocyte colony-stimulating factors (G-CSF) can be used to treat neutropenia, little is known about their safety during the BsAb initiation period and whether G-CSF can increase the risk of CRS.
By Alice Wang, David Nemirovsky, Andriy Derkach, Carlyn Tan, Issam S. Hamadeh, Ross Firestone, Eric Jurgens, Kevin Miller, Dhwani Patel, Neha Korde, Alexander M. Lesokhin, Sham Mailankody, Hani Hassoun, Hamza Hashmi, Sridevi Rajeeve, Urvi A. Shah, Kylee H. Maclachlan, Gunjan L. Shah, Michael Scordo, Heather Landau, Sergio A. Giralt, Saad Usmani, Malin Hultcrantz, Tala Shekarkhand
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Nature
Verified
Robust CD4 + CAR T cell expansion is associated with non-ICANS neurotoxicities after ciltacabtagene autoleucel in patients with multiple myeloma
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Editor’s summary Abstract Supplementary Materials REFERENCES AND NOTES Information & Authors Metrics & Citations Check Access References Figures Tables Media Share Editor’s summary The underlying cause of nonimmune effector cell–associated neurotoxicity syndrome neurotoxicities (NINTs) in patients treated with the chimeric antigen receptor T cell (CAR T cell) therapy ciltacabtagene autoleucel is poorly understood. Here, Jurgens et al.
By Lorena F Fernandes, Andre Matos, Eric Jurgens, Sneha Mitra, Kevin Herrera, David Nemirovsky, Andriy Derkach, Kinga Hosszu, Devin McAvoy, Ross Firestone, Sridevi Rajeeve, Alexander M. Lesokhin, Neha Korde, Carlyn Tan, Hamza Hashmi, Hani Hassoun, Kylee H. Maclachlan, Urvi A. Shah, Malin Hultcrantz, Maximilian Merz, Francesco Maura, Sergio A. Giralt, Gunjan L. Shah, Heather Landau, Brenden Bready
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Science Magazine
Verified
A differentiated effector T cell repertoire defines a functionally high-risk group of smoldering myeloma patients
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To the Editor: Smoldering multiple myeloma (SMM) is a precursor to active multiple myeloma (MM) characterized by a higher plasma cell burden than monoclonal gammopathy of undetermined significance (MGUS) but without evidence of the end-organ damage that defines MM [1, 2]. Current SMM guidelines advocate for close observation for progression to symptomatic progression to MM, with some studies suggesting the benefit of early intervention for patients with a high risk (HR) of progression [3].
By Ross Firestone, Anish K. Simhal, Jung Hun Oh, Kylee H. Maclachlan, Juan-Jose Garcés, Sham Mailankody, Hani Hassoun, Urvi A. Shah, Neha Korde, Carlyn Tan, Sridevi Rajeeve, Hamza Hashmi, Alexander M. Lesokhin, Kinga Hosszu, Francesco Maura, Joseph Deasy, Saad Usmani, Malin Hultcrantz, Theresia Akhlaghi, Devin McAvoy
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Nature
Verified
Functionally high-risk disease is associated with poor outcomes after late-line CAR T-cell therapy for multiple myeloma
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Abstract While CAR T has shown superior efficacy in earlier line of therapy [1, 2] for functionally high-risk multiple myeloma (FHRMM), outcomes with its use in later lines (3+) for FHR disease remain unknown. We describe a single-center experience of FHRMM patients (pts), defined as those with progression of disease (POD) < 24 months of frontline therapy, receiving CAR T-cell therapy.
By Hamza Hashmi, Tara M. Sebastian, Sridevi Rajeeve, Ross Firestone, Eric Jurgens, Kevin Miller, Francesco Maura, Alexander M. Lesokhin, Carlyn Tan, Gunjan L. Shah, Neha Korde, Heather Landau, Michael Scordo, Hani Hassoun, Kylee H. Maclachlan, Urvi A. Shah, Malin Hultcrantz, Andriy Derkach, David Nemirovsky, Sergio A. Giralt, Sham Mailankody, Saad Usmani, Tasmin Farzana, Maximillian Merz
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Nature
Verified
Genomics Define Malignant Transformation in Myeloma Precursor Conditions
1-5 These two clinical entities were defined over four decades ago based on the size of the aberrant plasma cell clone, and the classification criteria have not been revised since.6 Unlike other malignancies, the distinction of premalignancy from malignancy across this spectrum of neoplastic plasma cell disorders is not possible with standard morphologic or cytogenetic studies since they all share the same features.
Genomics Define Malignant Transformation in Myeloma Precursor Conditions
The following represents disclosure information provided by authors of this manuscript. All relationships are considered compensated unless otherwise noted. Relationships are self-held unless noted. I = Immediate Family Member, Inst = My Institution. Relationships may not relate to the subject matter of this manuscript. For more information about ASCO's conflict of interest policy, please refer to www.asco.org/rwc or ascopubs.org/jco/authors/author-center.
High WEE1 expression is independently linked to poor survival in multiple myeloma - Blood Cancer Journal
Abstract Current prognostic scores in multiple myeloma (MM) currently rely on disease burden and a limited set of genomic alterations. Some studies have suggested gene expression panels may predict clinical outcomes, but none are presently utilized in clinical practice. The tyrosine kinase WEE1 is a critical cell cycle regulator during the S-phase and G2M checkpoint.
High WEE1 expression is independently linked to poor survival in multiple myeloma
Abstract Current prognostic scores in multiple myeloma (MM) currently rely on disease burden and a limited set of genomic alterations. Some studies have suggested gene expression panels may predict clinical outcomes, but none are presently utilized in clinical practice. We therefore analyzed the MMRF CoMMpass dataset (N=659) and identified a high-risk group (top tertile) and a low-risk group ( bottom tertile) based on WEE1 expression sorted in descending order.
Slate’s parenting podcast on trailblazing and the summer slump.
Slate’s parenting podcast helps a woman who’s worried about being the first mom at her high-powered firm. Get Your Slate Plus Podcast If you can't access your feeds, please contact customer support. Thanks! Check your phone for a link to finish setting up your feed. Please enter a 10-digit phone number. Listen on your phone:RECOMMENDED Enter your phone number and we'll text you a link to set up the podcast in your app: We'll only text you about setting up this podcast, no spam.
The Transition-State Structure for Human MAT2A from Isotope Effects
Human methionine S-adenosyltransferase (MAT2A) catalyzes the formation of S-adenosylmethionine (SAM) from ATP and methionine. Synthetic lethal genetic analysis has identified MAT2A as an anticancer target in tumor cells lacking expression of 5?-methylthioadenosine phosphorylase (MTAP). Approximately 15% of human cancers are MTAP–/–. The remainder can be rendered MTAP– through MTAP inhibitors.
Swing, Swing, Swing: The Life & Times of Benny Goodman
books.google.com - Before Elvis Presley and rock-'n'-roll, another King ruled the roost of American popular music. His name was Benny Goodman and his domain, the gilded age of Swing. Benny's concerts, records, and radio shows catapulted the hot and controversial sounds of jazz into the hearts and homes of a hungry public....
Crosby, Gary & Ross Firestone
ISBN 10: 0385170556 / ISBN 13: 9780385170550 Published by Doubleday, 1983 Condition: Near Fine Hardcover Hardcover first edition is near fine. Unclipped jacket is toned, lightly soiled, and has wear along edges. Inscribed by Crosby to ffep. ; 8vo 8" - 9" tall; 304 pages; Signed by Author.
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