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Rósula García-Navas on Muck Rack

Rósula García-Navas

As seen in: Nature, MDPI, BioRxiv, American Society for Microbiology (ASM)
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Articles

Concomitant ablation of SOS1 and SOS2 triggers a lethal phenotype involving compromised intestinal integrity and widespread septicemia

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By Andrea Juan, Pablo Rodríguez-Ramos, Nuria Calzada, Carmela Gómez, Rocío Fuentes-Mateos, Alberto Fernández-Medarde, Rubén Nogueiras, David Diaz, David Díaz, Eugenio Santos, Rósula García-Navas, Alba Díaz-Aguilera
| Nature Verified
Abstract The RAS guanine nucleotide exchange factors Son of Sevenless 1 and 2 (SOS1 and SOS2) are key regulators of RAS signaling pathways controlling cellular proliferation, differentiation, and survival processes that are essential for correct tissue homeostasis. While mice lacking both SOS1 and SOS2 die precipitously, we demonstrate herein that the combined genetic ablation of SOS1 and SOS2 triggers spontaneous, gut-derived, lethal bacteremia.
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Pharmacological SOS1 inhibitor BI-3406 synergizes with BCR::ABL1 TKIs reducing leukemia stem cells and overcoming imatinib resistance in CML

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By Rósula García-Navas, Carmela Gómez, Andrea Juan, Alba Díaz-Aguilera, Nuria Calzada, Alberto Fernández-Medarde, Fermín Sánchez-Guijo, Dolors Colomer, Robyn L. Schenk, Marco H Hofmann, Kaja Kostyrko, Eugenio Santos, Anabel Clemente-Serrano, Belén Zamora-Valdivieso, Sara Pérez-Gutiérrez, Sonsoles Calvo-Jimenez, Magdalena Sierra
| Nature Verified
Abstract Disease persistence and resistance remain major challenges in chronic myeloid leukemia (CML). We evaluated pharmacological SOS1 inhibition with BI-3406, alone or in combination with BCR::ABL1 tyrosine-kinase inhibitors (TKI), across complementary preclinical models.
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Pharmacological SOS1 inhibitor BI-3406 demonstrates in vivo anti-tumor activity comparable to SOS1 genetic ablation in KRAS mutant tumors

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By Fernando C. Baltanas, Maximilian Kramer-Drauberg, Rósula García-Navas, Enrico Patrucco
| BioRxiv
Abstract Resistance to KRASmut inhibitors frequently arises, warranting further searches for anti-RAS cancer therapies. We evaluated the tolerability and efficacy of SOS1 pharmacological inhibition in comparison to genetic ablation in different KRAS-dependent tumor settings.
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