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Rotila Hyka on Muck Rack

Rotila Hyka

As seen in: Nature
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Articles

Exploiting an epigenetic resistance mechanism to PI3-kinase inhibition in leukemic stem cells

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By Shira G. Glushakow-Smith, Imit Kaur, Simone Sidoli, Shayda Hemmati, Ellen Angeles, Taneisha Sinclair, Samarpana Chakraborty, Kristina Ames, Swathi-Rao Narayanagari, Mark Soto, Melissa Tracy, Seiya Kitamura, Linde A. Miles, Ulrich Steidl, Aditi Shastri, Kira Gritsman, Aaliyah Battle, Rotila Hyka, Jayaram Vankudoth
| Nature Verified
Abstract Acquired non-genetic resistance mechanisms to existing therapies contribute to poor outcomes for acute myeloid leukemia (AML) patients, and the inability to target leukemic stem cells (LSCs) can lead to relapse. To overcome these challenges, we tested whether LSCs have dependencies on PI3- kinase (PI3K). We found that LSCs are susceptible to isoform-selective targeting of PI3K and are particularly dependent on the p110 alpha isoform of PI3K.
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