I have a hard time accepting “no” when the answer, in my opinion, should be the opposite, or when every guideline says “yes.” Nevertheless, my parents have prevailed in their complete rejection of undergoing colonoscopies, and, in the case of my mom, a mammogram as well. I have no insight into their future well-being, no warning about whether they wake up each morning and go to work carrying precancerous lesions slowly morphing into malignant masses.