Roy Gonzalez Aleman

Abstract Inter-residue communication forms a vast and intricate network that underpins essential biological processes such as catalysis, gene expression, and cell signaling. Allostery, a crucial phenomenon where distant regions of a macromolecule are energetically coupled to elicit functional responses, operates through these intricate communication networks within macromolecular complexes.

Abstract Histones post-translational modifications are major regulators of the chromatin dynamics. Understanding the structural signature of these marks in the nucleosome context is of major importance to unravel their mechanisms of action and open perspectives for the development of new therapies.