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Rubo Wang on Muck Rack

Rubo Wang

As seen in: Nature, BioRxiv
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Articles

De novo design of epitope-specific antibodies via a structure-driven computational workflow - Nature Communications

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By Yu Zhao, Fan Yang, Rubo Wang, Fang Wang, Zihan Wu, Longkai Huang
| Nature Verified
Abstract Accurate modeling of antibody-antigen complex structures holds significant potential for advancing biomedical research and the design of therapeutic antibodies. Compared to general proteins, progress in antibody structure prediction and design has been slow, and antibody discovery is still based on time-consuming animal immunization or library screening methods.
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IgGM: A Generative Model for Functional Antibody and Nanobody Design

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By Rubo Wang, Fandi Wu, Xingyu Gao, Jiaxiang Wu
| BioRxiv
Abstract Immunoglobulins are crucial proteins produced by the immune system to identify and bind to foreign substances, playing an essential role in shielding organisms from infections and diseases. Designing specific antibodies opens new pathways for disease treatment. With the rise of deep learning, AI-driven drug design has become possible, leading to several methods for antibody design.
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