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Regional differences in synaptic degeneration are linked to alpha-synuclein burden and axonal damage in Parkinson's disease and Dementia with Lewy bodies

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By Irene Frigerio, Maud MA Bouwman, Ruby TGMM Noordermeer, Ema Podobnik
| biorxiv.org
Abstract Regional differences in synaptic degeneration may underlie differences in clinical presentation and neuropathological disease progression in Parkinson's Disease (PD) and Dementia with Lewy bodies (DLB). Here, we mapped and quantified synaptic degeneration in cortical brain regions in PD, PD with dementia (PDD) and DLB, and assessed whether regional differences in synaptic loss are linked to axonal degeneration and neuropathological burden.
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